Advances in genotyping, phenotyping, and computational biology are converging to enhance our ability to more effectively discover, characterize, and use genetic diversity of crop species. Essential to progress is access to a wide array of agronomic diversity represented by a crop’s genepool. Now is the time to take advantage of our biological insights, analytical capabilities, and access to international ex situ collections and in situ populations of staple crops. Sorghum is an essential grain crop in the semi-arid tropics that serves as a dependable source of food, feed, and energy. Also, there are a significant number of accessions held in genebanks around the world; however, limited numbers of sorghum accessions have been utilized in crop improvement. In this presentation, we highlight how we are attempting to facilitate gene discovery and molecular breeding of sorghum, particularly as it relates to crops grown in semi-arid regions of the world that likely will subject to climate change in the 21st century.